|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Rat CD6 ORF mammalian expression plasmid, C-GFPSpark tag||RG80311-ACG|
|Rat CD6 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80311-ACR|
|Rat CD6 ORF mammalian expression plasmid, C-Flag tag||RG80311-CF|
|Rat CD6 ORF mammalian expression plasmid, C-His tag||RG80311-CH|
|Rat CD6 ORF mammalian expression plasmid, C-Myc tag||RG80311-CM|
|Rat CD6 ORF mammalian expression plasmid, C-HA tag||RG80311-CY|
|Rat CD6 Gene cDNA clone plasmid||RG80311-G|
|Rat CD6 ORF mammalian expression plasmid, N-Flag tag||RG80311-NF|
|Rat CD6 ORF mammalian expression plasmid, N-His tag||RG80311-NH|
|Rat CD6 ORF mammalian expression plasmid, N-Myc tag||RG80311-NM|
|Rat CD6 ORF mammalian expression plasmid, N-HA tag||RG80311-NY|
|Rat CD6 natural ORF mammalian expression plasmid||RG80311-UT|
|Learn more about expression Vectors|
T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.