|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Rat IL6ST ORF mammalian expression plasmid, C-GFPSpark tag||RG80030-ACG|
|Rat IL6ST ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80030-ACR|
|Rat IL6ST ORF mammalian expression plasmid, C-Flag tag||RG80030-CF|
|Rat IL6ST ORF mammalian expression plasmid, C-His tag||RG80030-CH|
|Rat IL6ST ORF mammalian expression plasmid, C-Myc tag||RG80030-CM|
|Rat IL6ST ORF mammalian expression plasmid, C-HA tag||RG80030-CY|
|Rat IL6ST Gene cDNA clone plasmid||RG80030-M|
|Rat IL6ST ORF mammalian expression plasmid, N-Flag tag||RG80030-NF|
|Rat IL6ST ORF mammalian expression plasmid, N-His tag||RG80030-NH|
|Rat IL6ST ORF mammalian expression plasmid, N-Myc tag||RG80030-NM|
|Rat IL6ST ORF mammalian expression plasmid, N-HA tag||RG80030-NY|
|Rat IL6ST natural ORF mammalian expression plasmid||RG80030-UT|
|Learn more about expression Vectors|
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.