|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse ESAM ORF mammalian expression plasmid, C-GFPSpark tag||MG50977-ACG|
|Mouse ESAM ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50977-ACR|
|Mouse ESAM ORF mammalian expression plasmid, C-Flag tag||MG50977-CF|
|Mouse ESAM ORF mammalian expression plasmid, C-His tag||MG50977-CH|
|Mouse ESAM ORF mammalian expression plasmid, C-Myc tag||MG50977-CM|
|Mouse ESAM ORF mammalian expression plasmid, C-HA tag||MG50977-CY|
|Mouse ESAM Gene cDNA clone plasmid||MG50977-G|
|Mouse ESAM ORF mammalian expression plasmid, N-Flag tag||MG50977-NF|
|Mouse ESAM ORF mammalian expression plasmid, N-His tag||MG50977-NH|
|Mouse ESAM ORF mammalian expression plasmid, N-Myc tag||MG50977-NM|
|Mouse ESAM ORF mammalian expression plasmid, N-HA tag||MG50977-NY|
|Mouse ESAM natural ORF mammalian expression plasmid||MG50977-UT|
|Learn more about expression Vectors|
Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.