|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse BCAM ORF mammalian expression plasmid, C-GFPSpark tag||MG50960-ACG|
|Mouse BCAM ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50960-ACR|
|Mouse BCAM ORF mammalian expression plasmid, C-Flag tag||MG50960-CF|
|Mouse BCAM ORF mammalian expression plasmid, C-His tag||MG50960-CH|
|Mouse BCAM ORF mammalian expression plasmid, C-Myc tag||MG50960-CM|
|Mouse BCAM ORF mammalian expression plasmid, C-HA tag||MG50960-CY|
|Mouse BCAM Gene cDNA clone plasmid||MG50960-G|
|Mouse BCAM ORF mammalian expression plasmid, N-Flag tag||MG50960-NF|
|Mouse BCAM ORF mammalian expression plasmid, N-His tag||MG50960-NH|
|Mouse BCAM ORF mammalian expression plasmid, N-Myc tag||MG50960-NM|
|Mouse BCAM ORF mammalian expression plasmid, N-HA tag||MG50960-NY|
|Mouse BCAM natural ORF mammalian expression plasmid||MG50960-UT|
|Learn more about expression Vectors|
The Lutheran (Lu) blood group and basal cell adhesion molecule (BCAM) antigens are both carried by 2 glycoprotein isoforms of the immunoglobulin superfamily representing receptors for the laminin alpha(5) chain. It is a transmembrane receptor with five immunoglobulin-like domains in its extracellular region, and is therefore classified as a member of the immunoglobulin (Ig) gene family. In addition to red blood cells, Lu/BCAM proteins are expressed in endothelial cells of vascular capillaries and in epithelial cells of several tissues. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. BCAM is upregulated following malignant transformation of some cell types in vivo and in vitro, thus being a candidate molecule involved in tumor progression. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes.