|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse NETO1 ORF mammalian expression plasmid, C-GFPSpark tag||MG50948-ACG|
|Mouse NETO1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50948-ACR|
|Mouse NETO1 ORF mammalian expression plasmid, C-Flag tag||MG50948-CF|
|Mouse NETO1 ORF mammalian expression plasmid, C-His tag||MG50948-CH|
|Mouse NETO1 ORF mammalian expression plasmid, C-Myc tag||MG50948-CM|
|Mouse NETO1 ORF mammalian expression plasmid, C-HA tag||MG50948-CY|
|Mouse NETO1 Gene cDNA clone plasmid||MG50948-G|
|Mouse NETO1 ORF mammalian expression plasmid, N-Flag tag||MG50948-NF|
|Mouse NETO1 ORF mammalian expression plasmid, N-His tag||MG50948-NH|
|Mouse NETO1 ORF mammalian expression plasmid, N-Myc tag||MG50948-NM|
|Mouse NETO1 ORF mammalian expression plasmid, N-HA tag||MG50948-NY|
|Mouse NETO1 natural ORF mammalian expression plasmid||MG50948-UT|
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Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus representing a novel subfamily of CUB- and LDLa-containing proteins. The cytoplasmic domains of NETO1 and NETO2 are not homologous to other known protein sequences but contain a conserved FXNPXY-like motif, which is essential for the internalization of clathrin coated pits during endocytosis or alternatively, may be implicated in intracellular signaling pathways. NETO1 and NETO2, have marked effects on receptor properties, increasing further the potential diversity of Kainate receptors (KARs) functional properties. NETO1 involves in the development and/or maintenance of neuronal circuitry. NETO1 regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory.