|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse FCER1A ORF mammalian expression plasmid, C-GFPSpark tag||MG50935-ACG|
|Mouse FCER1A ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50935-ACR|
|Mouse FCER1A ORF mammalian expression plasmid, C-Flag tag||MG50935-CF|
|Mouse FCER1A ORF mammalian expression plasmid, C-His tag||MG50935-CH|
|Mouse FCER1A ORF mammalian expression plasmid, C-Myc tag||MG50935-CM|
|Mouse FCER1A ORF mammalian expression plasmid, C-HA tag||MG50935-CY|
|Mouse FCER1A Gene cDNA clone plasmid||MG50935-G|
|Mouse FCER1A ORF mammalian expression plasmid, N-Flag tag||MG50935-NF|
|Mouse FCER1A ORF mammalian expression plasmid, N-His tag||MG50935-NH|
|Mouse FCER1A ORF mammalian expression plasmid, N-Myc tag||MG50935-NM|
|Mouse FCER1A ORF mammalian expression plasmid, N-HA tag||MG50935-NY|
|Mouse FCER1A natural ORF mammalian expression plasmid||MG50935-UT|
|Learn more about expression Vectors|
FcERI, also known as FCER1A, is the alpha subunit of the immunoglobulin epsilon receptor (IgE receptor). IgE receptor is a high affinity IgE receptor which plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. IgE receptor is comprised of an alpha subunit(FcERI), a beta subunit, and two gamma subunits. FcERI is glycosylated and contains 2 Ig-like (immunoglobulin-like) domains.