|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human GNB2L1 ORF mammalian expression plasmid, C-GFPSpark tag||HG16196-ACG|
|Human GNB2L1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG16196-ACR|
|Human GNB2L1 ORF mammalian expression plasmid, C-Flag tag||HG16196-CF|
|Human GNB2L1 ORF mammalian expression plasmid, C-His tag||HG16196-CH|
|Human GNB2L1 ORF mammalian expression plasmid, C-Myc tag||HG16196-CM|
|Human GNB2L1 ORF mammalian expression plasmid, C-HA tag||HG16196-CY|
|Human GNB2L1 Gene cDNA clone plasmid||HG16196-G|
|Human GNB2L1 ORF mammalian expression plasmid, N-Flag tag||HG16196-NF|
|Human GNB2L1 ORF mammalian expression plasmid, N-His tag||HG16196-NH|
|Human GNB2L1 ORF mammalian expression plasmid, N-Myc tag||HG16196-NM|
|Human GNB2L1 ORF mammalian expression plasmid, N-HA tag||HG16196-NY|
|Human GNB2L1 natural ORF mammalian expression plasmid||HG16196-UT|
|Learn more about expression Vectors|
RACK1 (guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1), also known as GNB2L1, contains 7 WD repeats and belongs to the WD repeat G protein beta family. In the liver, RACK1 is expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. It is up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue. RACK1 is involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. It interacts with a wide variety of proteins and plays a role in many cellular processes. GNB2L1 binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. RACK1 may recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. It inhibits the activity of SRC kinases including SRC, LCK and YES1. RACK1 also inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. It enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer.