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Human PDE9A Protein (His Tag)

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Human PDE9A Protein Product Information
Synonym:PDE9A, FLJ90181, HSPDE9A2
Protein Construction:A DNA sequence encoding the human PDE9A (O76083-2) C-terminal segment (Pro 181-Lys 506) was expressed, with a polyhistide tag at the N-terminus.
Expressed Host:E. coli
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human PDE9A Protein QC Testing
Purity:> 95 % as determined by SDS-PAGE
Endotoxin:Please contact us for more information.
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Met
Molecule Mass:The recombinant human PDE9A consisting of 337 amino acids and has a calculated molecular mass of 40 kDa. It migrates as an approximately 37 kDa band in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human PDE9A Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human PDE9A Protein SDS-PAGE
Human PDE9A Protein (His Tag) SDS-PAGE
Other PDE9A Recombinant Protein Products
PDE9A Background

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, also known as PDE9A, is a member of the cyclic nucleotide phosphodiesterase family and PDE9 subfamily. PDE9A is expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels of PDE9A is in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate. PDE9A mRNA is widely distributed throughout the rat and mouse brain, with the highest expression observed in cerebellar Purkinje cells. PDE9A is the only cGMP-specific PDE with significant expression in the forebrain, and as such is likely to play an important role in NO-cGMP signaling. PDE9A is highly conserved between species and is widely distributed throughout the rodent brain. PDE9A is probably involved in maintenance of low cGMP levels in cells and might play an important role in a variety of brain functions involving cGMP-mediated signal transduction. PDE9A hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. PDE9A represents a novel drug target worthy of further study.

Human PDE9A References
  • Andreeva, SG. et al., 2001,J Neurosci. 21 (22):9068-76.
  • van Staveren,WC. et al., 2002, J Neurocytol. 31 (8-9):729-41.
  • Almeida,CB. et al., 2008, Br J Haematol. 142 (5):836-44.
  • Kruse,L.S. et al., 2009, Brain Res. 1281 :25-34.
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    Catalog: 11745-H07E-20
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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.