|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse L1CAM ORF mammalian expression plasmid, C-GFPSpark tag||MG50835-ACG|
|Mouse L1CAM ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50835-ACR|
|Mouse L1CAM ORF mammalian expression plasmid, C-Flag tag||MG50835-CF|
|Mouse L1CAM ORF mammalian expression plasmid, C-His tag||MG50835-CH|
|Mouse L1CAM ORF mammalian expression plasmid, C-Myc tag||MG50835-CM|
|Mouse L1CAM ORF mammalian expression plasmid, C-HA tag||MG50835-CY|
|Mouse L1CAM Gene cDNA clone plasmid||MG50835-G|
|Mouse L1CAM natural ORF mammalian expression plasmid, HA tag||MG50835-G-Y|
|Mouse L1CAM ORF mammalian expression plasmid, N-Flag tag||MG50835-NF|
|Mouse L1CAM ORF mammalian expression plasmid, N-His tag||MG50835-NH|
|Mouse L1CAM ORF mammalian expression plasmid, N-Myc tag||MG50835-NM|
|Mouse L1CAM ORF mammalian expression plasmid, N-HA tag||MG50835-NY|
|Mouse L1CAM natural ORF mammalian expression plasmid||MG50835-UT|
|Learn more about expression Vectors|
L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan and intergrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait and adducted thumbs) and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy.