|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse MCAM ORF mammalian expression plasmid, C-GFPSpark tag||MG50794-ACG|
|Mouse MCAM ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50794-ACR|
|Mouse MCAM ORF mammalian expression plasmid, C-Flag tag||MG50794-CF|
|Mouse MCAM ORF mammalian expression plasmid, C-His tag||MG50794-CH|
|Mouse MCAM ORF mammalian expression plasmid, C-Myc tag||MG50794-CM|
|Mouse MCAM ORF mammalian expression plasmid, C-HA tag||MG50794-CY|
|Mouse MCAM Gene cDNA clone plasmid||MG50794-G|
|Mouse MCAM ORF mammalian expression plasmid, N-Flag tag||MG50794-NF|
|Mouse MCAM ORF mammalian expression plasmid, N-His tag||MG50794-NH|
|Mouse MCAM ORF mammalian expression plasmid, N-Myc tag||MG50794-NM|
|Mouse MCAM ORF mammalian expression plasmid, N-HA tag||MG50794-NY|
|Mouse MCAM natural ORF mammalian expression plasmid||MG50794-UT|
|Learn more about expression Vectors|
The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body, and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumours, and thus has been suggested to play an important role in tumour progression and the development of metastasis in certain human carcinomas.