|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse CDH2 ORF mammalian expression plasmid, C-GFPSpark tag||MG50752-ACG|
|Mouse CDH2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50752-ACR|
|Mouse CDH2 ORF mammalian expression plasmid, C-Flag tag||MG50752-CF|
|Mouse CDH2 ORF mammalian expression plasmid, C-His tag||MG50752-CH|
|Mouse CDH2 ORF mammalian expression plasmid, C-Myc tag||MG50752-CM|
|Mouse CDH2 ORF mammalian expression plasmid, C-HA tag||MG50752-CY|
|Mouse CDH2 Gene cDNA clone plasmid||MG50752-G|
|Mouse CDH2 ORF mammalian expression plasmid, N-Flag tag||MG50752-NF|
|Mouse CDH2 ORF mammalian expression plasmid, N-His tag||MG50752-NH|
|Mouse CDH2 ORF mammalian expression plasmid, N-Myc tag||MG50752-NM|
|Mouse CDH2 ORF mammalian expression plasmid, N-HA tag||MG50752-NY|
|Mouse CDH2 natural ORF mammalian expression plasmid||MG50752-UT|
|Learn more about expression Vectors|
Cadherins are calcium dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass tranmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-Cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-Cadherin promoted apoptosis. During apoptosis, N-Cadherin was cleaved into 20-100 kDa fragments. It may provide a novel target for therapies that are directed toward intimal proliferative disorders, including restenosis and vascular bypass graft failure. N-Cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression.