|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse CD8B ORF mammalian expression plasmid, C-GFPSpark tag||MG50646-ACG|
|Mouse CD8B ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50646-ACR|
|Mouse CD8B ORF mammalian expression plasmid, C-Flag tag||MG50646-CF|
|Mouse CD8B ORF mammalian expression plasmid, C-His tag||MG50646-CH|
|Mouse CD8B ORF mammalian expression plasmid, C-Myc tag||MG50646-CM|
|Mouse CD8B ORF mammalian expression plasmid, C-HA tag||MG50646-CY|
|Mouse CD8B Gene cDNA clone plasmid||MG50646-M|
|Mouse CD8B ORF mammalian expression plasmid, N-Flag tag||MG50646-NF|
|Mouse CD8B ORF mammalian expression plasmid, N-His tag||MG50646-NH|
|Mouse CD8B ORF mammalian expression plasmid, N-Myc tag||MG50646-NM|
|Mouse CD8B ORF mammalian expression plasmid, N-HA tag||MG50646-NY|
|Mouse CD8B natural ORF mammalian expression plasmid||MG50646-UT|
|Learn more about expression Vectors|
CD8B (CD8b molecule), also known as P37 and LEU2, contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. P37 gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. CD8 is thought to play a role in the process of T-cell mediated killing.