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ALDH7A1 / ATQ1 Antibody, Rabbit PAb, Antigen Affinity Purified

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Human ALDH7A1 Antibody Product Information
Immunogen:Recombinant Human ALDH7A1 protein (Catalog#11614-H07E)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human ALDH7A1 (rh ALDH7A1; Catalog#11614-H07E; P49419-2; Ser 2-Gln 511). ALDH7A1 specific IgG was purified by human ALDH7A1 affinity chromatography .
Human ALDH7A1 Antibody Usage Guide
Specificity:Human ALDH7A1 / ATQ1
Application:WB, ELISA, IHC-P, IP

WB: 10-20 μg/mL

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human ALDH7A1. The detection limit for Human ALDH7A1 is approximately 0.00975 ng/well.

IHC-P: 0.1-1 μg/mL

IP: 1-4 μg/mg of lysate

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human ALDH7A1 Antibody WB Application Image
ALDH7A1 / ATQ1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
Human ALDH7A1 Antibody IHC Application Image
[Click to enlarge image]
Caption:
Immunochemical staining of human ALDH7A1 in human hepatoma (from 3 donors) with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections).
ALDH7A1 / ATQ1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human ALDH7A1 in human hepatoma (from 3 donors) with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections).
ALDH7A1 / ATQ1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human ALDH7A1 in human liver (from 2 donors) with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections). The image showing positive staining of hepatocyte.
ALDH7A1 / ATQ1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Human ALDH7A1 Antibody IP Application Image
ALDH7A1 / ATQ1 Antibody, Rabbit PAb, Antigen Affinity Purified
Other ALDH7A1 Antibody Products
ALDH7A1 Background

ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Mammalian ALDH7A1 is homologous to plant ALDH7B1 which protects against various forms of stress such as increased salinity, dehydration and treatment with oxidants or pesticides. In mammals, ALDH7A1 is known to play a primary role during lysine catabolism through the NAD+-dependent oxidative conversion of aminoadipate semialdehyde (AASA) to its corresponding carboxylic acid, α-aminoadipic acid. Deleterious mutations in human ALDH7A1 are responsible for pyridoxine-dependent and folinic acid-responsive seizures. ALDH7A1 is a novel aldehyde dehydrogenase expressed in multiple subcellular compartments that protects against hyperosmotic stress by generating osmolytes and metabolizing toxic aldehydes.

Human ALDH7A1 References
  • Brocker C, et al. (2011) Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity. Chem Biol Interact. 191(1-3): 269-77.
  • Brocker C, et al. (2010) Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress. J Biol Chem. 285(24): 18452-63.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"