|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse EPHA7 ORF mammalian expression plasmid, C-GFPSpark tag||MG50587-ACG|
|Mouse EPHA7 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50587-ACR|
|Mouse EPHA7 ORF mammalian expression plasmid, C-Flag tag||MG50587-CF|
|Mouse EPHA7 ORF mammalian expression plasmid, C-His tag||MG50587-CH|
|Mouse EPHA7 ORF mammalian expression plasmid, C-Myc tag||MG50587-CM|
|Mouse EPHA7 ORF mammalian expression plasmid, C-HA tag||MG50587-CY|
|Mouse EPHA7 Gene cDNA clone plasmid||MG50587-M|
|Mouse EPHA7 ORF mammalian expression plasmid, N-Flag tag||MG50587-NF|
|Mouse EPHA7 ORF mammalian expression plasmid, N-His tag||MG50587-NH|
|Mouse EPHA7 ORF mammalian expression plasmid, N-Myc tag||MG50587-NM|
|Mouse EPHA7 ORF mammalian expression plasmid, N-HA tag||MG50587-NY|
|Mouse EPHA7 natural ORF mammalian expression plasmid||MG50587-UT|
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Ephrin type-A receptor 7, also known as EphA7, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Eph receptor-mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. The expression of EphA7 was reduced in all tested gastric cancer cell lines; however, there is marked variability in expression among gastric carcinoma specimens. EphA7 may have roles in the pathogenesis and development of gastric carcinomas.