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Human CDC42BPB Protein (His & GST Tag)

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Human CDC42BPB Protein Product Information
Synonym:DKFZp686H1431, FLJ37601, FLJ44730, KIAA1124, MRCKB
Protein Construction:A DNA sequence encoding the amino acid (Met 1-His 427) of human CDC42BPB (Q9Y5S2) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Expressed Host:Baculovirus-Insect Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human CDC42BPB Protein QC Testing
Purity:> 94 % as determined by SDS-PAGE
Bio-Activity:No Kinase Activity
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Met
Molecule Mass:The recombinant human CDC42BPB/GST chimera consists of 709 amino acids and has a calculated molecular mass of 82.4 kDa. It migrates as an approximately 70 kDa band in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile 50mM PBS, 500mM NaCl, 10% gly, 2mM GSH, pH 7.4
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human CDC42BPB Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human CDC42BPB Protein SDS-PAGE
Human CDC42BPB Protein (His & GST Tag) SDS-PAGE
Human CDC42BPB Protein (His & GST Tag) SDS-PAGE
Other CDC42BPB Recombinant Protein Products
CDC42BPB Background

CDC42BPB is a member of the serine / threonine protein kinase family that contains a Cdc42 / Rsc-binding p21 binding domain similar to that of PAK kinase. The kinase domain of this protein is related to the myotonic dystrophy kinase related ROK and this kinase may have functions in downstream regulating of Cdc42 in cytoskeletal recognization. It has been reported that the CDC42BPB protein take part in regulating numerous cellular functions by binding to members of a serine / threonine protein kinase subfamily. These functions include the remodeling of the cell cytoskeleton that is a feature of cell growth and differentiation.

Human CDC42BPB References
  • Moncrieff CL, et al. (1999) Cloning and Chromosomal Localization of Human Cdc42-Binding Protein Kinase beta.Genomics. 57 (2): 297-300.
  • Boyd Y, et al. (2001) Orthologs of seven genes (AKT1, CDC42BPB, DIO3, EIF5, JAG2, KLC, NDUFB1) from human Chromosome 14q32 map to distal chicken Chromosome 5. Mammalian Genome. 13 (2): 120-2.
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    Catalog: 11540-H20B-50
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