|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse BID ORF mammalian expression plasmid, C-GFPSpark tag||MG50351-ACG|
|Mouse BID ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50351-ACR|
|Mouse BID ORF mammalian expression plasmid, N-GFPSpark tag||MG50351-ANG|
|Mouse BID ORF mammalian expression plasmid, N-OFPSpark / RFP tag||MG50351-ANR|
|Mouse BID ORF mammalian expression plasmid, C-Flag tag||MG50351-CF|
|Mouse BID ORF mammalian expression plasmid, C-His tag||MG50351-CH|
|Mouse BID ORF mammalian expression plasmid, C-Myc tag||MG50351-CM|
|Mouse BID ORF mammalian expression plasmid, C-HA tag||MG50351-CY|
|Mouse BID Gene cDNA clone plasmid||MG50351-M|
|Mouse BID ORF mammalian expression plasmid, N-Flag tag||MG50351-NF|
|Mouse BID ORF mammalian expression plasmid, N-His tag||MG50351-NH|
|Mouse BID ORF mammalian expression plasmid, N-Myc tag||MG50351-NM|
|Mouse BID ORF mammalian expression plasmid, N-HA tag||MG50351-NY|
|Mouse BID natural ORF mammalian expression plasmid||MG50351-UT|
|Learn more about expression Vectors|
The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. Recent studies further indicate that Bid may be more than just a killer molecule, it could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint. BID is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent. BID is activated by Caspase 8 in response to Fas/TNF-R1 death receptor activation. Activated BID is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. BID action has been proposed to involve the mitochondrial re-location of its truncated form, tBid, to facilitate the release of apoptogenic proteins like cytochrome c.