|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
|Rat OLR1 ORF mammalian expression plasmid, C-GFPSpark tag||RG80268-ACG|
|Rat OLR1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80268-ACR|
|Rat OLR1 ORF mammalian expression plasmid, C-Flag tag||RG80268-CF|
|Rat OLR1 ORF mammalian expression plasmid, C-His tag||RG80268-CH|
|Rat OLR1 ORF mammalian expression plasmid, C-Myc tag||RG80268-CM|
|Rat OLR1 ORF mammalian expression plasmid, C-HA tag||RG80268-CY|
|Rat OLR1 Gene cDNA clone plasmid||RG80268-G|
|Rat OLR1 ORF mammalian expression plasmid, N-Flag tag||RG80268-NF|
|Rat OLR1 ORF mammalian expression plasmid, N-His tag||RG80268-NH|
|Rat OLR1 ORF mammalian expression plasmid, N-Myc tag||RG80268-NM|
|Rat OLR1 ORF mammalian expression plasmid, N-HA tag||RG80268-NY|
|Rat OLR1 natural ORF mammalian expression plasmid||RG80268-UT|
|Learn more about expression Vectors|
Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX1), is a receptor protein that belongs to the C-type lectin superfamily. LOX1 is a multi-ligand receptor originally identified as the endothelial oxidized LDL receptor. OLR1 / LOX1 was isolated from an aortic endothelial cell, and recently it has been discovered in macrophages and vascular smooth muscle cells in artery vessels. The expression of LOX1 is inducted by inflammatory stimuli and oxidative stimuli. This protein binds, internalizes and degrades oxidized low-density lipoprotein. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. In clinical, LOX1 is thought to be involved in the development of atherosclerotic lesions.