|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse IGFBP4 ORF mammalian expression plasmid, C-GFPSpark tag||MG50250-ACG|
|Mouse IGFBP4 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50250-ACR|
|Mouse IGFBP4 ORF mammalian expression plasmid, C-Flag tag||MG50250-CF|
|Mouse IGFBP4 ORF mammalian expression plasmid, C-His tag||MG50250-CH|
|Mouse IGFBP4 ORF mammalian expression plasmid, C-Myc tag||MG50250-CM|
|Mouse IGFBP4 ORF mammalian expression plasmid, C-HA tag||MG50250-CY|
|Mouse IGFBP4 Gene cDNA clone plasmid||MG50250-M|
|Mouse IGFBP4 ORF mammalian expression plasmid, N-Flag tag||MG50250-NF|
|Mouse IGFBP4 ORF mammalian expression plasmid, N-His tag||MG50250-NH|
|Mouse IGFBP4 ORF mammalian expression plasmid, N-Myc tag||MG50250-NM|
|Mouse IGFBP4 ORF mammalian expression plasmid, N-HA tag||MG50250-NY|
|Mouse IGFBP4 natural ORF mammalian expression plasmid||MG50250-UT|
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Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are clearly distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF, or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. Expression of IGFBP-4 mRNA in nontransgenic littermates was maximal in liver and kidney. IGFBP-4 is a functional antagonist of IGF-I action on SMC. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.