|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
|Rat IL17RA ORF mammalian expression plasmid, C-GFPSpark tag||RG80190-ACG|
|Rat IL17RA ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80190-ACR|
|Rat IL17RA ORF mammalian expression plasmid, C-Flag tag||RG80190-CF|
|Rat IL17RA ORF mammalian expression plasmid, C-His tag||RG80190-CH|
|Rat IL17RA ORF mammalian expression plasmid, C-Myc tag||RG80190-CM|
|Rat IL17RA ORF mammalian expression plasmid, C-HA tag||RG80190-CY|
|Rat IL17RA Gene cDNA clone plasmid||RG80190-G|
|Rat IL17RA ORF mammalian expression plasmid, N-Flag tag||RG80190-NF|
|Rat IL17RA ORF mammalian expression plasmid, N-His tag||RG80190-NH|
|Rat IL17RA ORF mammalian expression plasmid, N-Myc tag||RG80190-NM|
|Rat IL17RA ORF mammalian expression plasmid, N-HA tag||RG80190-NY|
|Rat IL17RA natural ORF mammalian expression plasmid||RG80190-UT|
|Learn more about expression Vectors|
Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.