|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Mouse ROBO4 ORF mammalian expression plasmid, C-GFPSpark tag||MG51081-ACG|
|Mouse ROBO4 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG51081-ACR|
|Mouse ROBO4 ORF mammalian expression plasmid, C-Flag tag||MG51081-CF|
|Mouse ROBO4 ORF mammalian expression plasmid, C-His tag||MG51081-CH|
|Mouse ROBO4 ORF mammalian expression plasmid, C-Myc tag||MG51081-CM|
|Mouse ROBO4 ORF mammalian expression plasmid, C-HA tag||MG51081-CY|
|Mouse ROBO4 Gene cDNA clone plasmid||MG51081-G|
|Mouse ROBO4 ORF mammalian expression plasmid, N-Flag tag||MG51081-NF|
|Mouse ROBO4 ORF mammalian expression plasmid, N-His tag||MG51081-NH|
|Mouse ROBO4 ORF mammalian expression plasmid, N-Myc tag||MG51081-NM|
|Mouse ROBO4 ORF mammalian expression plasmid, N-HA tag||MG51081-NY|
|Mouse ROBO4 natural ORF mammalian expression plasmid||MG51081-UT|
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Roundabout homolog 4, also known as magic roundabout and ROBO4 is a member of the immunoglobulin superfamily and ROBO family. ROBO4 is specifically expressed in endothelial cells. It is expressed at sites of angiogenesis in different tumor types. ROBO4 contains two fibronectin type-III domains and two Ig-like C2-type (immunoglobulin-like) domains. ROBO4 is the fourth identified member of the roundabout receptor family. It is the only Robo family member expressed in primary endothelial cells and that application of Slit inhibits their migration. ROBO4 is predominantly expressed in embryonic or tumor vascular endothelium and is considered important for vascular development and as a candidate tumor endothelial marker. ROBO4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development. ROBO4 is a receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. ROBO4 may mediate the inhibition of primary endothelial cell migration by Slit proteins. Activating ROBO4 may have broad therapeutic application in diseases characterized by excessive angiogenesis and/or vascular leak.