|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
|Rat TNFRSF13C ORF mammalian expression plasmid, C-GFPSpark tag||RG80171-ACG|
|Rat TNFRSF13C ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80171-ACR|
|Rat TNFRSF13C ORF mammalian expression plasmid, C-Flag tag||RG80171-CF|
|Rat TNFRSF13C ORF mammalian expression plasmid, C-His tag||RG80171-CH|
|Rat TNFRSF13C ORF mammalian expression plasmid, C-Myc tag||RG80171-CM|
|Rat TNFRSF13C ORF mammalian expression plasmid, C-HA tag||RG80171-CY|
|Rat TNFRSF13C Gene cDNA clone plasmid||RG80171-G|
|Rat TNFRSF13C ORF mammalian expression plasmid, N-Flag tag||RG80171-NF|
|Rat TNFRSF13C ORF mammalian expression plasmid, N-His tag||RG80171-NH|
|Rat TNFRSF13C ORF mammalian expression plasmid, N-Myc tag||RG80171-NM|
|Rat TNFRSF13C ORF mammalian expression plasmid, N-HA tag||RG80171-NY|
|Rat TNFRSF13C natural ORF mammalian expression plasmid||RG80171-UT|
|Learn more about expression Vectors|
Tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen, is a member of the tumor necrosis factor receptor superfamily. A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein which is important in determining the outcome of the response. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors or tumour necrosis factor (TNFR), on their surface. Tumour necrosis factors (TNFR) detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.