|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse SLAMF7 ORF mammalian expression plasmid, C-GFPSpark tag||MG50201-ACG|
|Mouse SLAMF7 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50201-ACR|
|Mouse SLAMF7 ORF mammalian expression plasmid, C-Flag tag||MG50201-CF|
|Mouse SLAMF7 ORF mammalian expression plasmid, C-His tag||MG50201-CH|
|Mouse SLAMF7 ORF mammalian expression plasmid, C-Myc tag||MG50201-CM|
|Mouse SLAMF7 ORF mammalian expression plasmid, C-HA tag||MG50201-CY|
|Mouse SLAMF7 Gene cDNA clone plasmid||MG50201-M|
|Mouse SLAMF7 ORF mammalian expression plasmid, N-Flag tag||MG50201-NF|
|Mouse SLAMF7 ORF mammalian expression plasmid, N-His tag||MG50201-NH|
|Mouse SLAMF7 ORF mammalian expression plasmid, N-Myc tag||MG50201-NM|
|Mouse SLAMF7 ORF mammalian expression plasmid, N-HA tag||MG50201-NY|
|Mouse SLAMF7 natural ORF mammalian expression plasmid||MG50201-UT|
|Learn more about expression Vectors|
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.