|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse PLAUR ORF mammalian expression plasmid, C-GFPSpark tag||MG50160-ACG|
|Mouse PLAUR ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50160-ACR|
|Mouse PLAUR ORF mammalian expression plasmid, C-Flag tag||MG50160-CF|
|Mouse PLAUR ORF mammalian expression plasmid, C-His tag||MG50160-CH|
|Mouse PLAUR ORF mammalian expression plasmid, C-Myc tag||MG50160-CM|
|Mouse PLAUR ORF mammalian expression plasmid, C-HA tag||MG50160-CY|
|Mouse PLAUR Gene cDNA clone plasmid||MG50160-M|
|Mouse PLAUR ORF mammalian expression plasmid, N-Flag tag||MG50160-NF|
|Mouse PLAUR ORF mammalian expression plasmid, N-His tag||MG50160-NH|
|Mouse PLAUR ORF mammalian expression plasmid, N-Myc tag||MG50160-NM|
|Mouse PLAUR ORF mammalian expression plasmid, N-HA tag||MG50160-NY|
|Mouse PLAUR natural ORF mammalian expression plasmid||MG50160-UT|
|Learn more about expression Vectors|
Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. uPAR and uPA levels in both resected tumor tissue and plasma are of independent prognostic significance for patient survival in several types of human cancer. This system has classically been thought to drive tumor progression by mediating directed extracellular proteolysis on the surface of migrating or invading cells, and intervening with this proteolysis by targeting uPAR has been proposed to represent a novel approach for inhibiting tumor progression. uPAR, also known as PLAUR or CD87, has been implicated in the growth, metastasis, and angiogenesis of several solid and hemotologic malignancies. uPAR is a highly glycosylated, 55-60kDa integral membrane protein linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. It is part of a cell surface system that also consists of the serine protease uPA and several specific inhibitors (plasminogen activator inhibitors 1 and 2). Additionally, the analysis of CD87 (urokinase-type plasminogen activator receptor - uPAR) expression has a potential role in the diagnostic or prognostic work-up of several hematological malignancies, particularly acute leukemia and multiple myeloma.