|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Mouse GPC3 ORF mammalian expression plasmid, C-GFPSpark tag||MG50989-ACG|
|Mouse GPC3 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50989-ACR|
|Mouse GPC3 ORF mammalian expression plasmid, C-Flag tag||MG50989-CF|
|Mouse GPC3 ORF mammalian expression plasmid, C-His tag||MG50989-CH|
|Mouse GPC3 ORF mammalian expression plasmid, C-Myc tag||MG50989-CM|
|Mouse GPC3 ORF mammalian expression plasmid, C-HA tag||MG50989-CY|
|Mouse GPC3 Gene cDNA clone plasmid||MG50989-G|
|Mouse GPC3 ORF mammalian expression plasmid, N-Flag tag||MG50989-NF|
|Mouse GPC3 ORF mammalian expression plasmid, N-His tag||MG50989-NH|
|Mouse GPC3 ORF mammalian expression plasmid, N-Myc tag||MG50989-NM|
|Mouse GPC3 ORF mammalian expression plasmid, N-HA tag||MG50989-NY|
|Mouse GPC3 natural ORF mammalian expression plasmid||MG50989-UT|
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Glypican-3, also known as Intestinal protein OCI-5, GPC3, and OCI5, is a member of the glypican family. It belongs to the glypican family and is highly expressed in lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still controversial. Thus, Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.