|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse CXCL10 ORF mammalian expression plasmid, C-GFPSpark tag||MG50139-ACG|
|Mouse CXCL10 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50139-ACR|
|Mouse CXCL10 ORF mammalian expression plasmid, C-Flag tag||MG50139-CF|
|Mouse CXCL10 ORF mammalian expression plasmid, C-His tag||MG50139-CH|
|Mouse CXCL10 ORF mammalian expression plasmid, C-Myc tag||MG50139-CM|
|Mouse CXCL10 ORF mammalian expression plasmid, C-HA tag||MG50139-CY|
|Mouse CXCL10 Gene cDNA clone plasmid||MG50139-M|
|Mouse CXCL10 ORF mammalian expression plasmid, N-Flag tag||MG50139-NF|
|Mouse CXCL10 ORF mammalian expression plasmid, N-His tag||MG50139-NH|
|Mouse CXCL10 ORF mammalian expression plasmid, N-Myc tag||MG50139-NM|
|Mouse CXCL10 ORF mammalian expression plasmid, N-HA tag||MG50139-NY|
|Mouse CXCL10 natural ORF mammalian expression plasmid||MG50139-UT|
|Learn more about expression Vectors|
CXCL10, also known as crg-2, is a chemokine of the CXC subfamily and ligand for the receptor CXCR3. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL10 has a three-dimensional crystal structure. Its signaling is mediated by the g protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. It is chemotactic for monocytes and T-lymphocytes. CXCL10 can be secreted by several cell types in response to IFN-γ. Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1 or 4 who do not achieve a sustained viral response (SVR) after completion of antiviral therapy.