|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse IL6 ORF mammalian expression plasmid, C-GFPSpark tag||MG50136-ACG|
|Mouse IL6 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50136-ACR|
|Mouse IL6 ORF mammalian expression plasmid, C-Flag tag||MG50136-CF|
|Mouse IL6 ORF mammalian expression plasmid, C-His tag||MG50136-CH|
|Mouse IL6 ORF mammalian expression plasmid, C-Myc tag||MG50136-CM|
|Mouse IL6 ORF mammalian expression plasmid, C-HA tag||MG50136-CY|
|Mouse IL6 Gene cDNA clone plasmid||MG50136-M|
|Mouse IL6 ORF mammalian expression plasmid, N-Flag tag||MG50136-NF|
|Mouse IL6 ORF mammalian expression plasmid, N-His tag||MG50136-NH|
|Mouse IL6 ORF mammalian expression plasmid, N-Myc tag||MG50136-NM|
|Mouse IL6 ORF mammalian expression plasmid, N-HA tag||MG50136-NY|
|Mouse IL6 natural ORF mammalian expression plasmid||MG50136-UT|
|Learn more about expression Vectors|
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.