|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Mouse B2M ORF mammalian expression plasmid, C-GFPSpark tag||MG50957-ACG|
|Mouse B2M ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50957-ACR|
|Mouse B2M ORF mammalian expression plasmid, C-Flag tag||MG50957-CF|
|Mouse B2M ORF mammalian expression plasmid, C-His tag||MG50957-CH|
|Mouse B2M ORF mammalian expression plasmid, C-Myc tag||MG50957-CM|
|Mouse B2M ORF mammalian expression plasmid, C-HA tag||MG50957-CY|
|Mouse B2M Gene cDNA clone plasmid||MG50957-G|
|Mouse B2M ORF mammalian expression plasmid, N-Flag tag||MG50957-NF|
|Mouse B2M ORF mammalian expression plasmid, N-His tag||MG50957-NH|
|Mouse B2M ORF mammalian expression plasmid, N-Myc tag||MG50957-NM|
|Mouse B2M ORF mammalian expression plasmid, N-HA tag||MG50957-NY|
|Mouse B2M natural ORF mammalian expression plasmid||MG50957-UT|
|Learn more about expression Vectors|
B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα3 chain. Unlikeα3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M(β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV.