|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse MBL ORF mammalian expression plasmid, C-GFPSpark tag||MG50063-ACG|
|Mouse MBL ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50063-ACR|
|Mouse MBL ORF mammalian expression plasmid, C-Flag tag||MG50063-CF|
|Mouse MBL ORF mammalian expression plasmid, C-His tag||MG50063-CH|
|Mouse MBL ORF mammalian expression plasmid, C-Myc tag||MG50063-CM|
|Mouse MBL ORF mammalian expression plasmid, C-HA tag||MG50063-CY|
|Mouse MBL Gene cDNA clone plasmid||MG50063-M|
|Mouse MBL ORF mammalian expression plasmid, N-Flag tag||MG50063-NF|
|Mouse MBL ORF mammalian expression plasmid, N-His tag||MG50063-NH|
|Mouse MBL ORF mammalian expression plasmid, N-Myc tag||MG50063-NM|
|Mouse MBL ORF mammalian expression plasmid, N-HA tag||MG50063-NY|
|Mouse MBL natural ORF mammalian expression plasmid||MG50063-UT|
|Learn more about expression Vectors|
MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcome for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.