|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse CCL5 ORF mammalian expression plasmid, C-GFPSpark tag||MG50022-ACG|
|Mouse CCL5 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50022-ACR|
|Mouse CCL5 ORF mammalian expression plasmid, C-Flag tag||MG50022-CF|
|Mouse CCL5 ORF mammalian expression plasmid, C-His tag||MG50022-CH|
|Mouse CCL5 ORF mammalian expression plasmid, C-Myc tag||MG50022-CM|
|Mouse CCL5 ORF mammalian expression plasmid, C-HA tag||MG50022-CY|
|Mouse CCL5 Gene cDNA clone plasmid||MG50022-M|
|Mouse CCL5 ORF mammalian expression plasmid, N-Flag tag||MG50022-NF|
|Mouse CCL5 ORF mammalian expression plasmid, N-His tag||MG50022-NH|
|Mouse CCL5 ORF mammalian expression plasmid, N-Myc tag||MG50022-NM|
|Mouse CCL5 ORF mammalian expression plasmid, N-HA tag||MG50022-NY|
|Mouse CCL5 natural ORF mammalian expression plasmid||MG50022-UT|
|Learn more about expression Vectors|
Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokin ligand 5(CCL5) is chemotactic for T cells, basophils and eosinophils. Chemokin ligand 5(CCL5) has been considered a HIV-supressor secreted by CD8+ T cells and other immune cells. Chemokin ligand 5(CCL5) is a key to activating recruit leukocytes into inflammatory sites and in the presence of particular cytokines released by T cells, it can change the NK cells into CHAK cells.