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Human ANGPTL5 Protein (GST Tag)

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Human ANGPTL5 Protein Product Information
Protein Construction:A DNA sequence encoding the mature form of human ANGPTL5 (NP_835228.2) (Asn 26-Lys 388) was fused with the GST tag at the N-terminus.
Expressed Host:Baculovirus-Insect Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human ANGPTL5 Protein QC Testing
Purity:> 90 % as determined by SDS-PAGE
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Met
Molecule Mass:The recombinant human ANGPTL5/GST chimera consists of 588 amino acids and predicts a molecular mass of 68 kDa as estimated in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8, 0.5mM GSH, 0.5mM PMSF, 0.5mM EDTA
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human ANGPTL5 Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human ANGPTL5 Protein SDS-PAGE
Human ANGPTL5 Protein (GST Tag) SDS-PAGE
Other ANGPTL5 Recombinant Protein Products
ANGPTL5 Background

The angiopoietins are protein growth factors that promote angiogenesis, the formation of blood vessels from pre-existing blood vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4. In addition, there are a number of proteins that are closely related to angiopoietins (ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL5, ANGPTL6, ANGPTL7). Angiopoietin-like 5 (ANGPTL5) is mainly expressed in adult heart. Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. ANGPTL5 are regulators of lipoprotein metabolism in humans. ANGPTL5 plays nonredundant roles in TG metabolism, and multiple alleles at these loci cumulatively contribute to variability in plasma TG levels in humans.

Human ANGPTL5 References
  • Miida T, et al. (2010) Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events. Curr Opin Lipidol. 21(1): 70-5.
  • Romeo S, et al. (2009) Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. J Clin Invest. 119(1): 70-9.
  • Zeng L, et al. (2003) Identification of a novel human angiopoietin-like gene expressed mainly in heart. J Hum Genet. 48(3): 159-62.
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    Catalog: 11094-H09B-50
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