|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Mouse SLAMF8 ORF mammalian expression plasmid, C-GFPSpark tag||MG50623-ACG|
|Mouse SLAMF8 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50623-ACR|
|Mouse SLAMF8 ORF mammalian expression plasmid, C-Flag tag||MG50623-CF|
|Mouse SLAMF8 ORF mammalian expression plasmid, C-His tag||MG50623-CH|
|Mouse SLAMF8 ORF mammalian expression plasmid, C-Myc tag||MG50623-CM|
|Mouse SLAMF8 ORF mammalian expression plasmid, C-HA tag||MG50623-CY|
|Mouse SLAMF8 Gene cDNA clone plasmid||MG50623-M|
|Mouse SLAMF8 ORF mammalian expression plasmid, N-Flag tag||MG50623-NF|
|Mouse SLAMF8 ORF mammalian expression plasmid, N-His tag||MG50623-NH|
|Mouse SLAMF8 ORF mammalian expression plasmid, N-Myc tag||MG50623-NM|
|Mouse SLAMF8 ORF mammalian expression plasmid, N-HA tag||MG50623-NY|
|Mouse SLAMF8 natural ORF mammalian expression plasmid||MG50623-UT|
|Learn more about expression Vectors|
The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules, a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells.
Mouse SLAM family member 8, also known as B-lymphocyte activator macrophage expressed, BCM-like membrane protein, SLAMF8 and BLAME, is a single-pass type I membrane protein. It contains one Ig-like C2-type (immunoglobulin-like) domain. SLAMF8 / BLAME is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.