|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Mouse FZD10 ORF mammalian expression plasmid, C-GFPSpark tag||MG50568-ACG|
|Mouse FZD10 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50568-ACR|
|Mouse FZD10 ORF mammalian expression plasmid, C-Flag tag||MG50568-CF|
|Mouse FZD10 ORF mammalian expression plasmid, C-His tag||MG50568-CH|
|Mouse FZD10 ORF mammalian expression plasmid, C-Myc tag||MG50568-CM|
|Mouse FZD10 ORF mammalian expression plasmid, C-HA tag||MG50568-CY|
|Mouse FZD10 Gene cDNA clone plasmid||MG50568-M|
|Mouse FZD10 ORF mammalian expression plasmid, N-Flag tag||MG50568-NF|
|Mouse FZD10 ORF mammalian expression plasmid, N-His tag||MG50568-NH|
|Mouse FZD10 ORF mammalian expression plasmid, N-Myc tag||MG50568-NM|
|Mouse FZD10 ORF mammalian expression plasmid, N-HA tag||MG50568-NY|
|Mouse FZD10 natural ORF mammalian expression plasmid||MG50568-UT|
|Learn more about expression Vectors|
Mouse Frizzled-10, also known as Fz-10, CD350 and FZD10, is a multi-pass membrane protein which belongs to the G-protein coupled receptor Fz/Smo family. Frizzled-10 / FZD10 is abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. It is weakly expressed in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate. Frizzled-10 / FZD10 is a receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Frizzled-10 / FZD10 may also be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.