After search, choose a molecule or a kind of categories listed in the left to narrow down your filter. If you have any problems, please contact us!
Text Size:AAA

Human IL22BP / IL22RA2 Protein (His Tag)

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
Human IL22BP/IL22RA2 Protein Product Information
Synonym:IL22RA2, CRF2-10, CRF2-S1, CRF2X, IL-22BP, MGC150509, MGC150510
Protein Construction:A DNA sequence encoding the human IL22RA2 isoform 2 (NP_851826.1) (Met 1-Pro 231) was expressed, fused with a polyhistidine tag at the C-terminus.
Expressed Host:Human Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human IL22BP/IL22RA2 Protein QC Testing
Purity:> 95 % as determined by SDS-PAGE
Bio-Activity:Immobilized IL22BP-His at 10 μg/ml (100 μl/well) can bind biotinylated IL22 (Cat:13059-HNAE), The EC50 of biotinylated IL22 (Cat:13059-HNAE) is 1.78-4.14 ng/ml.
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Thr 22
Molecule Mass:The secreted recombinant human IL22RA2 comprises 221 amino acids with a predicted molecular mass of 26.1 kDa. As a result of glycosylation, rh IL22RA2 migrates as an approximately 50-55 kDa band in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human IL22BP/IL22RA2 Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Other IL22BP/IL22RA2 Recombinant Protein Products
IL-22BP/IL-22RA2 Background

Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22-binding protein (IL-22BP), is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. It is expressed in placenta, spleen, breast, skin and lung. It is also detected in intestinal tract, testis, brain, heart and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered, a membrane-bound receptor and a soluble receptor.

Human IL-22BP/IL-22RA2 References
  • Whittington HA, et al. (2004) Interleukin-22: a potential immunomodulatory molecule in the lung. Am J Respir Cell Mol Biol. 31(2): 220-6.
  • Dumoutier L, et al. (2001) Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J Immunol. 166(12): 7090-5.
  • Wei CC, et al. (2003) Cloning and characterization of mouse IL-22 binding protein. Genes Immun. 4(3): 204-11.
  • Size / Price
    Catalog: 11025-H08H-20
    List Price:   (Save )
    Price:      [How to order]
    AvailabilityIn StockShipping instructions