|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Mouse MERTK ORF mammalian expression plasmid, C-GFPSpark tag||MG50514-ACG|
|Mouse MERTK ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50514-ACR|
|Mouse MERTK ORF mammalian expression plasmid, C-Flag tag||MG50514-CF|
|Mouse MERTK ORF mammalian expression plasmid, C-His tag||MG50514-CH|
|Mouse MERTK ORF mammalian expression plasmid, C-Myc tag||MG50514-CM|
|Mouse MERTK ORF mammalian expression plasmid, C-HA tag||MG50514-CY|
|Mouse MERTK Gene cDNA clone plasmid||MG50514-M|
|Mouse MERTK ORF mammalian expression plasmid, N-Flag tag||MG50514-NF|
|Mouse MERTK ORF mammalian expression plasmid, N-His tag||MG50514-NH|
|Mouse MERTK ORF mammalian expression plasmid, N-Myc tag||MG50514-NM|
|Mouse MERTK ORF mammalian expression plasmid, N-HA tag||MG50514-NY|
|Mouse MERTK natural ORF mammalian expression plasmid||MG50514-UT|
|Learn more about expression Vectors|
&Proto-oncogene tyrosine-protein kinase MER (MERTK) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MERTK is localized in membrane and is no expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. This protein is highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver. MERTK regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. MERTK plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Defects in MERTK are the cause of retinitis pigmentosa type 38.