|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Mouse AGER ORF mammalian expression plasmid, C-GFPSpark tag||MG50489-ACG|
|Mouse AGER ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50489-ACR|
|Mouse AGER ORF mammalian expression plasmid, C-Flag tag||MG50489-CF|
|Mouse AGER ORF mammalian expression plasmid, C-His tag||MG50489-CH|
|Mouse AGER ORF mammalian expression plasmid, C-Myc tag||MG50489-CM|
|Mouse AGER ORF mammalian expression plasmid, C-HA tag||MG50489-CY|
|Mouse AGER Gene cDNA clone plasmid||MG50489-M|
|Mouse AGER ORF mammalian expression plasmid, N-Flag tag||MG50489-NF|
|Mouse AGER ORF mammalian expression plasmid, N-His tag||MG50489-NH|
|Mouse AGER ORF mammalian expression plasmid, N-Myc tag||MG50489-NM|
|Mouse AGER ORF mammalian expression plasmid, N-HA tag||MG50489-NY|
|Mouse AGER natural ORF mammalian expression plasmid||MG50489-UT|
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Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certain members of the S100/calgranulin family of proteins, high mobility group box 1 (HMGB1), advanced oxidation protein products, and amyloid (beta-sheet fibrils). Initial studies investigating the role of RAGE in renal dysfunction focused on diabetes, neurodegenerative disorders, and inflammatory responses. However, RAGE also has roles in the pathogenesis of renal disorders that are not associated with diabetes, such as obesity-related glomerulopathy, doxorubicin-induced nephropathy, hypertensive nephropathy, lupus nephritis, renal amyloidosis, and ischemic renal injuries. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including atherosclerosis, arthritis, Alzheimer's disease, atherosclerosis and aging associated diseases.