|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Mouse PDGF-C ORF mammalian expression plasmid, C-GFPSpark tag||MG50458-ACG|
|Mouse PDGF-C ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50458-ACR|
|Mouse PDGF-C ORF mammalian expression plasmid, C-Flag tag||MG50458-CF|
|Mouse PDGF-C ORF mammalian expression plasmid, C-His tag||MG50458-CH|
|Mouse PDGF-C ORF mammalian expression plasmid, C-Myc tag||MG50458-CM|
|Mouse PDGF-C ORF mammalian expression plasmid, C-HA tag||MG50458-CY|
|Mouse PDGF-C Gene cDNA clone plasmid||MG50458-M|
|Mouse PDGF-C ORF mammalian expression plasmid, N-Flag tag||MG50458-NF|
|Mouse PDGF-C ORF mammalian expression plasmid, N-His tag||MG50458-NH|
|Mouse PDGF-C ORF mammalian expression plasmid, N-Myc tag||MG50458-NM|
|Mouse PDGF-C ORF mammalian expression plasmid, N-HA tag||MG50458-NY|
|Mouse PDGF-C natural ORF mammalian expression plasmid||MG50458-UT|
|Learn more about expression Vectors|
PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyrosine kinase activity. They have roles in the regulation of many biological processes including embryonic development, angiogenesis, cell proliferation and differentiation, and contribute to the pathophysiology of some diseases, including cancer. There are two isoforms of the PDGFR receptor; PDGFRalpha and PDGFRbeta, which can form homo- or heterodimers. The endogenous PDGFR ligands are PDGF-A, -B, -C and -D, which induce receptor dimerization and transphosphorylation at specific tyrosine residues upon binding. This activates the intracellular kinase activity, initiating intracellular signaling through the MAPK, PI 3-K and PKCgamma pathways. PDGF-C acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. PDGF-C Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs.