|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Mouse TrkC ORF mammalian expression plasmid, C-GFPSpark tag||MG50320-ACG|
|Mouse TrkC ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50320-ACR|
|Mouse TrkC ORF mammalian expression plasmid, C-Flag tag||MG50320-CF|
|Mouse TrkC ORF mammalian expression plasmid, C-His tag||MG50320-CH|
|Mouse TrkC ORF mammalian expression plasmid, C-Myc tag||MG50320-CM|
|Mouse TrkC ORF mammalian expression plasmid, C-HA tag||MG50320-CY|
|Mouse TrkC Gene cDNA clone plasmid||MG50320-G|
|Mouse TrkC ORF mammalian expression plasmid, N-Flag tag||MG50320-NF|
|Mouse TrkC ORF mammalian expression plasmid, N-His tag||MG50320-NH|
|Mouse TrkC ORF mammalian expression plasmid, N-Myc tag||MG50320-NM|
|Mouse TrkC ORF mammalian expression plasmid, N-HA tag||MG50320-NY|
|Mouse TrkC natural ORF mammalian expression plasmid||MG50320-UT|
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NT-3 growth factor receptor also known as neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase or Trk-C receptor, is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC/NTRK3 is widely expressed in the developing and adult nervous system. In later embryonic development, TrkC/NTRK3 is expressed in various structures of the CNS including the caudatoputamen, septal nuclei, cerebellum, and brainstem. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. In the PNS, trkC hybridization appears to correlate, both temporally and spatially, with the outgrowth of axons toward their peripheral targets. TrkC/NTRK3 is widely expressed in the three identified branches of the mammalian nervous system and appears to correlate with the expression of NT-3, its cognate ligand. The apparent colocalization of trkC transcripts with NT-3 raises the possibility this neurotrophin exerts its trophic effects by a paracrine and/or autocrine mechanism. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in TrkC encoding gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.