|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Mouse PDPN ORF mammalian expression plasmid, C-GFPSpark tag||MG50256-ACG|
|Mouse PDPN ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50256-ACR|
|Mouse PDPN ORF mammalian expression plasmid, C-Flag tag||MG50256-CF|
|Mouse PDPN ORF mammalian expression plasmid, C-His tag||MG50256-CH|
|Mouse PDPN ORF mammalian expression plasmid, C-Myc tag||MG50256-CM|
|Mouse PDPN ORF mammalian expression plasmid, C-HA tag||MG50256-CY|
|Mouse PDPN Gene cDNA clone plasmid||MG50256-M|
|Mouse PDPN ORF mammalian expression plasmid, N-Flag tag||MG50256-NF|
|Mouse PDPN ORF mammalian expression plasmid, N-His tag||MG50256-NH|
|Mouse PDPN ORF mammalian expression plasmid, N-Myc tag||MG50256-NM|
|Mouse PDPN ORF mammalian expression plasmid, N-HA tag||MG50256-NY|
|Mouse PDPN natural ORF mammalian expression plasmid||MG50256-UT|
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Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.