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Human RSK3 / RPS6KA2 Protein (GST Tag)

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RSK3Protein Product Information
Synonym:RP1-168L15.2, HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, pp90RSK3
Protein Construction:A DNA sequence encoding the human RPS6KA2 isoform 1 (Q15349-1) (Met 1-Leu 733) was fused with the GST tag at the N-terminus.
Species:Human
Expressed Host:Baculovirus-Insect Cells
Form & Shipping:Liquid. It is shipped out with blue ice.
RSK3Protein QC Testing
Purity:> 84 % as determined by SDS-PAGE
Bio-Activity:The specific activity was determined to be 41 nmol/min/mg using synthetic RSK peptide (KRRRLSSLRA) as substrate (see protocol for kinase assay).
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Met
Molecule Mass:The recombinant human RPS6KA2/GST chimera consists of 957 amino acids and migrates as an approximatly 110 kDa band in SDS-PAGE under reducing conditions as predicted.
Formulation:Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.0, 20mM GSH
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
RSK3Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:
10833-H09B
Background

Ribosomal protein S6 kinase alpha-2, also known as 90 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA2 / RSK-3 is expressed in many tissues. Highest expression is in lung and skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 arrest, increased apoptosis, reduced levels of phosphorylated extracellular signal-regulated kinase and altered other cell cycle proteins. RPS6KA2 / RSK-3 contains one AGC-kinase C-terminal domain and two protein kinase domains. It forms a complex with either ERK1 or ERK2 in quiescent cells. It transiently dissociates following mitogenic stimulation. RPS6KA2 / RSK-3 is a serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 are involved in several pathways central to the carcinogenic process, including regulation of cell growth, insulin, and inflammation. 

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Catalog:10833-H09B-20
List Price: $138.00  (Save $0.00)
Price:$138.00      [How to order]
Availabilityon Sale
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  • Human RSK3 / RPS6KA2 Protein (GST Tag) SDS-PAGE
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