|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Mouse CLEC7A ORF mammalian expression plasmid, C-GFPSpark tag||MG50233-ACG|
|Mouse CLEC7A ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50233-ACR|
|Mouse CLEC7A ORF mammalian expression plasmid, C-Flag tag||MG50233-CF|
|Mouse CLEC7A ORF mammalian expression plasmid, C-His tag||MG50233-CH|
|Mouse CLEC7A ORF mammalian expression plasmid, C-Myc tag||MG50233-CM|
|Mouse CLEC7A ORF mammalian expression plasmid, C-HA tag||MG50233-CY|
|Mouse CLEC7A Gene cDNA clone plasmid||MG50233-M|
|Mouse CLEC7A ORF mammalian expression plasmid, N-Flag tag||MG50233-NF|
|Mouse CLEC7A ORF mammalian expression plasmid, N-His tag||MG50233-NH|
|Mouse CLEC7A ORF mammalian expression plasmid, N-Myc tag||MG50233-NM|
|Mouse CLEC7A ORF mammalian expression plasmid, N-HA tag||MG50233-NY|
|Mouse CLEC7A natural ORF mammalian expression plasmid||MG50233-UT|
|Learn more about expression Vectors|
Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.