|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Recombinant Human CD66c protein (Catalog#10823-H08H)|
|0.1M Sodium phosphate, 0.15M NaCl, pH 7.2, 3% BSA|
|Produced in rabbits immunized with purified, recombinant Human CEACAM6 / CD66c (rh CEACAM6; Catalog#10823-H08H; NP_002474.3; Met 1-Gly 320). CEACAM6 specific IgG was purified by human CEACAM6 affinity chromatography.|
|Human CD66c / CEACAM6|
This antibody can be used at 1-2 μg/mL as a detection antibody in sandwich ELISA (SEK10823).
|This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.|
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It s a glycosylphosphatidylinositol-linked immunoglobulin superfamily member that is overexpressed in a variety of human cancers, including colon, breast and lung and is associated with tumourigenesis, tumour cell adhesion, invasion and metastasis. CEACAM6 is a unique mediator of migration and invasion of drug resistant oestrogen-deprived breast cancer cells, and this protein could be an important biomarker of metastasis. CEACAM6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.