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Cynomolgus monkey CLPS Gene cDNA Clone (full-length ORF Clone)

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CLPScDNA Clone Product Information
Gene_bank_ref_id:unsubmitted
cDNA Size:396
cDNA Description:ORF Clone of Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) colipase, pancreatic DNA.
Gene Synonym:CLPS
Species:Cynomolgus
Vector:pUC19 Vector
Restriction Site:
Tag Sequence:
Sequence Description:Identical with XM_001116700.2 [ Macaca mulatta (Rhesus monkey) ]: 333T/C not causing the amino acid variation; 191G/A(S64N). Please check the sequence information before order.
Shipping_carrier:Each tube contains approximately 10 μg of lyophilized plasmid.
Storage:The lyophilized plasmid can be stored at ambient temperature for three months.
pUC19 vector Vector Information:

pUC19 is a small, high-copy number E. coli plasmid cloning vector, of which multiple cloning sites as shown below. The molecule is a small double-stranded circle, 2686 base pairs in length. pUC19 encodes the N-terminal fragment of b-galactosidase (lacZa), which allows for blue/white colony screening (i.e., a-complementation), as well as a pUC origin of replication.

pUC19 vector Usage Suggestion:

The coding sequence can be amplified by PCR with M13-47 and RV-M primers.

Vector Sequence Download
Cynomolgus monkey CLPS Gene cDNA Clone (full-length ORF Clone) on other vectors
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Cynomolgus monkey CLPS Gene cDNA Clone (full-length ORF Clone), expression ready, N-OFPSpark tagCG90523-ANR$325
Cynomolgus monkey CLPS Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-taggedCG90523-CF$295
Cynomolgus monkey CLPS Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-taggedCG90523-CH$295
Cynomolgus monkey CLPS Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-taggedCG90523-CM$295
Cynomolgus monkey CLPS Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-taggedCG90523-CY$295
Cynomolgus monkey CLPS Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-taggedCG90523-NF$295
Cynomolgus monkey CLPS Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-taggedCG90523-NH$295
Cynomolgus monkey CLPS Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-taggedCG90523-NM$295
Cynomolgus monkey CLPS Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-taggedCG90523-NY$295
Cynomolgus monkey CLPS Gene cDNA Clone (full-length ORF Clone)CG90523-U$95
Cynomolgus monkey CLPS Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedCG90523-UT$295
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Background

Colipase belongs to the colipase family. Structural studies of the complex and of colipase alone have revealed the functionality of its architecture. It is a small protein with five conserved disulphide bonds. Structural analogies have been recognised between a developmental protein, the pancreatic lipase C-terminal domain, the N-terminal domains of lipoxygenases and the C-terminal domain of alpha-toxin. Colipase can only be detected in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Colipase allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Colipase is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilising as active conformation and considerably increasing the overall hydrophobic binding site.

References
  • Davis RC, et al. (1991) Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. Genomics. 10(1):262-5.
  • Lowe ME. (1997) Structure and function of pancreatic lipase and colipase. Annu Rev Nutr. 17: 141-58.
  • Verger R, et al. (1999) Colipase: structure and interaction with pancreatic lipase. Biochim Biophys Acta. 1441(2-3):173-84.
  • Size / Price
    Catalog:CG90523-U
    List Price: $95.00  (Save $0.00)
    Price:$95.00      [How to order]
    Availability5 business days
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