|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Mouse PLAUR ORF mammalian expression plasmid, C-GFPSpark tag||MG50160-ACG|
|Mouse PLAUR ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50160-ACR|
|Mouse PLAUR ORF mammalian expression plasmid, C-Flag tag||MG50160-CF|
|Mouse PLAUR ORF mammalian expression plasmid, C-His tag||MG50160-CH|
|Mouse PLAUR ORF mammalian expression plasmid, C-Myc tag||MG50160-CM|
|Mouse PLAUR ORF mammalian expression plasmid, C-HA tag||MG50160-CY|
|Mouse PLAUR Gene cDNA clone plasmid||MG50160-M|
|Mouse PLAUR ORF mammalian expression plasmid, N-Flag tag||MG50160-NF|
|Mouse PLAUR ORF mammalian expression plasmid, N-His tag||MG50160-NH|
|Mouse PLAUR ORF mammalian expression plasmid, N-Myc tag||MG50160-NM|
|Mouse PLAUR ORF mammalian expression plasmid, N-HA tag||MG50160-NY|
|Mouse PLAUR natural ORF mammalian expression plasmid||MG50160-UT|
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Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. uPAR and uPA levels in both resected tumor tissue and plasma are of independent prognostic significance for patient survival in several types of human cancer. This system has classically been thought to drive tumor progression by mediating directed extracellular proteolysis on the surface of migrating or invading cells, and intervening with this proteolysis by targeting uPAR has been proposed to represent a novel approach for inhibiting tumor progression. uPAR, also known as PLAUR or CD87, has been implicated in the growth, metastasis, and angiogenesis of several solid and hemotologic malignancies. uPAR is a highly glycosylated, 55-60kDa integral membrane protein linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. It is part of a cell surface system that also consists of the serine protease uPA and several specific inhibitors (plasminogen activator inhibitors 1 and 2). Additionally, the analysis of CD87 (urokinase-type plasminogen activator receptor - uPAR) expression has a potential role in the diagnostic or prognostic work-up of several hematological malignancies, particularly acute leukemia and multiple myeloma.