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CD208 / LAMP3 / DC-LAMP Antibody, Rabbit PAb, Antigen Affinity Purified

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Human CD208/DC-LAMP/LAMP3 Antibody Product Information
Immunogen:Recombinant Human CD208 protein (Catalog#10527-H08H)
Clone ID:
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human CD208 / LAMP3 (rh CD208; Catalog#10527-H08H; NP_055213.2; Lys 28-Thr 381). LAMP3 specific IgG was purified by human LAMP3 affinity chromatography.
Human CD208/DC-LAMP/LAMP3 Antibody Usage Guide
Specificity:Human CD208 / LAMP3 / DC-LAMP
Application:ELISA, IHC-P

ELISA: 0.5-1.0 μg/mL

This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human LAMP3. The detection limit for Human LAMP3 is 0.00245 ng/well.

IHC-P: 1-10 μg/mL

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human CD208/DC-LAMP/LAMP3 Antibody IHC Application Image
[Click to enlarge image]
Immunohistochemical staining of formalin fixed, paraffin-embedded human lymphonode (1 μg/mL).
CD208 / LAMP3 / DC-LAMP Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Other CD208/DC-LAMP/LAMP3 Antibody Products
CD208/DC-LAMP Background

Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces.

Human CD208/DC-LAMP References
  • Salaun B, et al. (2003) Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP. Eur J Immunol. 33(9): 2619-29.
  • Salaun B, et al. (2004) CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Am J Pathol. 164(3): 861-71.
  • Ishigami S, et al. (2010) Prognostic value of CD208-positive cell infiltration in gastric cancer. Cancer Immunol Immunother. 59(3): 389-95.
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