|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Mouse FGFR4 ORF mammalian expression plasmid, C-GFPSpark tag||MG50194-ACG|
|Mouse FGFR4 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50194-ACR|
|Mouse FGFR4 ORF mammalian expression plasmid, C-Flag tag||MG50194-CF|
|Mouse FGFR4 ORF mammalian expression plasmid, C-His tag||MG50194-CH|
|Mouse FGFR4 ORF mammalian expression plasmid, C-Myc tag||MG50194-CM|
|Mouse FGFR4 ORF mammalian expression plasmid, C-HA tag||MG50194-CY|
|Mouse FGFR4 Gene cDNA clone plasmid||MG50194-M|
|Mouse FGFR4 ORF mammalian expression plasmid, N-Flag tag||MG50194-NF|
|Mouse FGFR4 ORF mammalian expression plasmid, N-His tag||MG50194-NH|
|Mouse FGFR4 ORF mammalian expression plasmid, N-Myc tag||MG50194-NM|
|Mouse FGFR4 ORF mammalian expression plasmid, N-HA tag||MG50194-NY|
|Mouse FGFR4 natural ORF mammalian expression plasmid||MG50194-UT|
|Learn more about expression Vectors|
Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.