|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human LIF ORF mammalian expression plasmid, C-GFPSpark tag||HG14890-ACG|
|Human LIF ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG14890-ACR|
|Human LIF ORF mammalian expression plasmid, C-Flag tag||HG14890-CF|
|Human LIF ORF mammalian expression plasmid, C-His tag||HG14890-CH|
|Human LIF ORF mammalian expression plasmid, C-Myc tag||HG14890-CM|
|Human LIF ORF mammalian expression plasmid, C-HA tag||HG14890-CY|
|Human LIF Gene cDNA Clone (full-length ORF Clone)||HG14890-G|
|Human LIF ORF mammalian expression plasmid, N-Flag tag||HG14890-NF|
|Human LIF ORF mammalian expression plasmid, N-His tag||HG14890-NH|
|Human LIF ORF mammalian expression plasmid, N-Myc tag||HG14890-NM|
|Human LIF ORF mammalian expression plasmid, N-HA tag||HG14890-NY|
|Human LIF natural ORF mammalian expression plasmid||HG14890-UT|
|Learn more about expression Vectors|
Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It’s involved in growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. LIF has potent proinflammatory property, being the inducer of the acute phase protein synthesis and affecting the cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic and neuronal cells. LIF binds to the specific LIF receptor (LIFR-α) which forms a heterodimer with a specific subunit common to all members of that family of receptors, the GP130 signal transducing subunit. This leads to activation of the JAK/STAT and MAPK cascades. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origin.