|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
|Mouse MOG ORF mammalian expression plasmid, C-GFPSpark tag||MG51046-ACG|
|Mouse MOG ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG51046-ACR|
|Mouse MOG ORF mammalian expression plasmid, C-Flag tag||MG51046-CF|
|Mouse MOG ORF mammalian expression plasmid, C-His tag||MG51046-CH|
|Mouse MOG ORF mammalian expression plasmid, C-Myc tag||MG51046-CM|
|Mouse MOG ORF mammalian expression plasmid, C-HA tag||MG51046-CY|
|Mouse MOG Gene cDNA clone plasmid||MG51046-G|
|Mouse MOG ORF mammalian expression plasmid, N-Flag tag||MG51046-NF|
|Mouse MOG ORF mammalian expression plasmid, N-His tag||MG51046-NH|
|Mouse MOG ORF mammalian expression plasmid, N-Myc tag||MG51046-NM|
|Mouse MOG ORF mammalian expression plasmid, N-HA tag||MG51046-NY|
|Mouse MOG natural ORF mammalian expression plasmid||MG51046-UT|
|Learn more about expression Vectors|
Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals.