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EGFR / HER1 / ErbB1 Antibody (FITC), Mouse MAb

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
EGFR/ErbB1/HER1Antibody Product Information
Immunogen:Recombinant Human EGFR / HER1 / ErbB1 protein (Catalog#10001-H08H)
Clone ID:08
Ig Type:Mouse IgG1
Concentration:1 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EGFR / HER1 / ErbB1 (rh EGFR / HER1 / ErbB1; Catalog#10001-H08H; NP_005219; Met 1-Ser 645) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
EGFR/ErbB1/HER1Antibody Usage Guide
Specificity:Human EGFR / HER1 / ErbB1
No cross-reactivity in ELISA with
Human ErbB2
Human ErbB3
Human ErbB4
Application:FCM
Storage:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Images
EGFR / HER1 / ErbB1 Antibody (FITC), Mouse MAb, Flow cytometric analysis
[Click to enlarge image]
Caption:
Flow cytometric analysis of EGFR expression on human A431 cells.
Background

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

References
  • Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25.
  • Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48.
  • Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.
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    Size / Price
    Catalog:10001-MM08-F-50
    List Price: $130.00  (Save $0.00)
    Price:$130.00      [How to order]
    Availabilityon Sale
    Images
    • EGFR / HER1 / ErbB1 Antibody (FITC), Mouse MAb, Flow cytometric analysis
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