|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Mouse MBL1 ORF mammalian expression plasmid, C-GFPSpark tag||MG50069-ACG|
|Mouse MBL1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50069-ACR|
|Mouse MBL1 ORF mammalian expression plasmid, C-Flag tag||MG50069-CF|
|Mouse MBL1 ORF mammalian expression plasmid, C-His tag||MG50069-CH|
|Mouse MBL1 ORF mammalian expression plasmid, C-Myc tag||MG50069-CM|
|Mouse MBL1 ORF mammalian expression plasmid, C-HA tag||MG50069-CY|
|Mouse MBL1 Gene cDNA clone plasmid||MG50069-M|
|Mouse MBL1 ORF mammalian expression plasmid, N-Flag tag||MG50069-NF|
|Mouse MBL1 ORF mammalian expression plasmid, N-His tag||MG50069-NH|
|Mouse MBL1 ORF mammalian expression plasmid, N-Myc tag||MG50069-NM|
|Mouse MBL1 ORF mammalian expression plasmid, N-HA tag||MG50069-NY|
|Mouse MBL1 natural ORF mammalian expression plasmid||MG50069-UT|
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Mannose-binding lectin (MBL), also named mannose or mannan-binding protein (MBP), is a C-type lectin which participates in the innate immune system as an activator of the complement system and as opsonin after binding to certain carbohydrate structures on microorganisms and pathogens. Its function appears to be pattern recognition in the first line of defense in the pre-immune host. MBL recognizes carbohydrate patterns found on the surface of a large number of pathogenic micro-organisms including bacteria, viruses, protozoa and fungi. Binding of MBL to a micro-organism results in activation of the lectin pathway of the complement system. Two forms of MBL, MBL-A and MBL-C, were characterized in rodents, rabbits, bovine and rhesus monkeys, whereas only one form was identified in humans, chimpanzees and chickens. The two forms are encoded by two distinct genes named MBL1 and MBL2, which have been identified in many species including the pig. The MBL1 and MBL2 genes encode mannan-binding lectins (MBL) A and C, respectively, that are collagenous lectins (collectins) produced mainly by the liver. The MBL1 gene encodes MBL-A, which has bacteria-binding properties in pigs and rodents but is mutated to a pseudogene in humans and chimpanzees. Deficiency of MBL is probably the most common human immunodeficiency and is associated with an increased risk of mucosally acquired infections including meningococcal disease. MBL could modify disease susceptibility by modulating macrophage interactions with mucosal organisms at the site of initial acquisition.