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Human CD47 Protein

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Reactivity: Human  
Application: ELISA  
    12283-R006-50
    12283-R006-100
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      12283-R001-50
      12283-R001-100
      50 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        12283-T16-50
        12283-T16-200
        12283-T16-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          12283-RP01-400
          12283-RP01-200
          12283-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Mouse  
          Application: 
          • Slide 1
          • Slide 1
          101928-T08-50
          101928-T08-200
          101928-T08-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Rat  
          Application: ELISA  
            80305-RP01-400
            80305-RP01-200
            80305-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Rat  
            Application: ELISA  WB  
            • Slide 1
            80305-T48-50
            80305-T48-200
            80305-T48-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Rat  
            Application: ELISA  
              80305-MM08-50
              80305-MM08-200
              80305-MM08-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart

              HP101891 

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              CD47 protein Background

              CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.

              Immune Checkpoint
              Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: WB Antibodies
              Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

              Immunotherapy   Cancer Immunotherapy   Targeted Therapy

              Human CD47 protein References
            • Brown EJ, et al. (2001) Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 11(3): 130-5.
            • Oldenborg PA. (2004) Role of CD47 in erythroid cells and in autoimmunity. Leuk Lymphoma. 45(7): 1319-27.
            • Kaczorowski DJ, et al. (2007) Targeting CD47: NO limit on therapeutic potential. Circ Res. 100(5): 602-3.
            • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"